Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester

Base Information

• Chemical Name: Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester
• CAS No.: 121667-99-0
• Molecular Formula: C₃₃H₃₇N₂O₈PS₂
• Molecular Weight: 684.771
• Mol file: 121667-99-0.mol

Synonyms:

Chemical Property of Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester

There total 2 articles about Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diisopropylamino-3'-O-<5'-O-(dimethoxytrityl) thymidine>thiomethoxyphosphine (121667-97-8,121668-00-6) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester (121667-99-0,121668-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H-tetrazole / benzene / Ambient temperature

2: S₈/pyridine / 0.17 h / Ambient temperature

With pyridine; 1H-tetrazole; sulfur; In benzene;

DOI:10.1016/S0040-4039(00)88455-5

Reference yield:

Thiophosphorous acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester (121667-98-9,121668-02-8) → Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester (121667-99-0,121668-03-9)

Guidance literature:

With pyridine; sulfur; for 0.166667h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88455-5

upstream raw materials:

Thiophosphorous acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,O'-dimethyl ester

N,N-diisopropylamino-3'-O-<5'-O-(dimethoxytrityl) thymidine>thiomethoxyphosphine