ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Base Information

• Chemical Name: ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
• CAS No.: 104305-94-4
• Molecular Formula: C₂₀H₂₂N₂O₈
• Molecular Weight: 418.403
• Mol file: 104305-94-4.mol

Synonyms:

Chemical Property of ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

There total 1 articles about ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.3%

3-nitro-benzaldehyde (99-61-6) + ethoxycarbonylmethyl acetoacetate (57582-45-3) + methyl 3-aminocrotonate (14205-39-1) → ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (104305-94-4)

Guidance literature:

In di-isopropyl ether; for 7h; Heating;

DOI:10.1248/cpb.33.3787

Reference yield: 64.0%

ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (104305-94-4) → carboxymethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (104305-95-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Ambient temperature;

DOI:10.1248/cpb.33.3787

Reference yield:

ethoxycarbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (104305-94-4) → (4-diphenylmethyl-1-piperazinyl)carbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (104305-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / KOH / ethanol / 3 h / Ambient temperature

2: 1.) thionyl chloride; 2.) K₂CO₃ / 1.) CHCl₃: r.t., 20 min.; ref., 10 min.; 2.) benzene, ref., 2 h

With potassium hydroxide; thionyl chloride; potassium carbonate; In ethanol;

DOI:10.1248/cpb.33.3787

upstream raw materials:

3-nitro-benzaldehyde

ethoxycarbonylmethyl acetoacetate

methyl 3-aminocrotonate

Downstream raw materials:

carboxymethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

(4-diphenylmethyl-1-piperazinyl)carbonylmethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Refernces