-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Base Information

Chemical Name:-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester
CAS No.:166169-73-9
Molecular Formula:C₄₉H₆₂N₄O₆S₂
Molecular Weight:867.186
Hs Code.:

<R-(R*,S*)>-N-<<2-<N-<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of -N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Chemical Property:

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Technology Process of -N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

There total 6 articles about -N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 166169-73-9
-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NMP, diisopropylethylamine, hydroxybenzotriazole, diisopropylethylamine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 4 deg C, 5 min, 2.) CH₂Cl₂, RT, 16 h

2: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

3: 1.) PyBroP, N,N-diisopropylethylamine, (dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, from 0 deg C to RT, 3 h

4: 325 mg / 4 N HCl in dioxane, triethylsilane / 2 h / Ambient temperature

5: 1.) acetic acid, 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, 2.5 h

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; triethylsilane; dmap; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm950642a

Reference yield:

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 166169-73-9
-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NMP, diisopropylethylamine, hydroxybenzotriazole, diisopropylethylamine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 4 deg C, 5 min, 2.) CH₂Cl₂, RT, 16 h

2: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

3: 1.) PyBroP, N,N-diisopropylethylamine, (dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, from 0 deg C to RT, 3 h

4: 325 mg / 4 N HCl in dioxane, triethylsilane / 2 h / Ambient temperature

5: 1.) acetic acid, 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, 2.5 h

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; triethylsilane; dmap; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm950642a

Reference yield:

: 166168-88-3
(R^*)-N-<<2-<(1,1-dimethylethoxy)carbonyl>1,2,3,4-tetrahydro-3-isoquinoinyl>carbonyl>-L-methionine, methyl ester

: 166169-73-9
-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-3-methyl-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-methionine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

2: 1.) PyBroP, N,N-diisopropylethylamine, (dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, from 0 deg C to RT, 3 h

3: 325 mg / 4 N HCl in dioxane, triethylsilane / 2 h / Ambient temperature

4: 1.) acetic acid, 2.) NaCNBH₃ / 1.) MeOH, 5 min, 2.) MeOH, 2.5 h

With hydrogenchloride; triethylsilane; dmap; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm950642a