(S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

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Chemical Name:(S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid
CAS No.:83599-10-4
Molecular Formula:C₂HF₃O₂*C₂₇H₄₁N₇O₈
Molecular Weight:705.689
Hs Code.:

(S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

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Chemical Property of (S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

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Technology Process of (S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

There total 6 articles about (S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83599-08-0
BOC-Val-Gly-Gly-Ala-Ala-Gln-OBzl

: 83599-10-4
(S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 0 ℃; for 1h;
DOI:10.1248/cpb.30.2433

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 83599-10-4
(S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 74.8 percent / DCC, Et₃N / dimethylformamide / 15 h / Ambient temperature

2: 89.1 percent / 80percent hydrazine hydrate / methanol

3: 1.) isoamyl nitrite, HCl, 2.) Et₃N / 1.) DMF, 0 deg C, 2.) DMF, 5 deg C, 40 h

4: trifluoroacetic acid, anisole / 1 h / 0 °C

With hydrogenchloride; hydrazine hydrate; methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; isopentyl nitrite; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.2433

Reference yield:

: 83599-03-5
BOC-Val-Gly-Gly-OMe

: 83599-10-4
(S)-2-[(S)-2-((S)-2-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-acetylamino]-acetylamino}-propionylamino)-propionylamino]-4-carbamoyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 89.1 percent / 80percent hydrazine hydrate / methanol

2: 1.) isoamyl nitrite, HCl, 2.) Et₃N / 1.) DMF, 0 deg C, 2.) DMF, 5 deg C, 40 h

3: trifluoroacetic acid, anisole / 1 h / 0 °C

With hydrogenchloride; hydrazine hydrate; methoxybenzene; triethylamine; trifluoroacetic acid; isopentyl nitrite; In methanol;
DOI:10.1248/cpb.30.2433