1-benzylspiro-2'-ol

Base Information

Chemical Name:1-benzylspiro-2'-ol
CAS No.:95417-65-5
Molecular Formula:C₂₁H₂₅NO
Molecular Weight:307.436
Hs Code.:

1-benzylspiro<piperidine-4,1'-tetralin>-2'-ol

Synonyms:

Suppliers and Price of 1-benzylspiro-2'-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzylspiro-2'-ol

Chemical Property:

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Technology Process of 1-benzylspiro-2'-ol

There total 3 articles about 1-benzylspiro-2'-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 95449-63-1
9b-(N-benzylcarbamoylmethyl)-1,2,3a,4,5,9b-hexahydronaphtho<2,1-b>furan-2-one

: 95417-65-5
1-benzylspiro-2'-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Heating;
DOI:10.1248/cpb.32.3561

Reference yield:

: 95417-64-4
1,1-bis(methoxycarbonylmethyl)-2-tetralone

: 95417-65-5
1-benzylspiro-2'-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / NaBH₄ / 3 h / Ambient temperature

2: 1.) 10percent KOH / 1.) MeOH, H₂O, reflux, 30 min; 2.) 180 deg C, 4 h

3: 59 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

With potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1248/cpb.32.3561

Reference yield:

: 95449-62-0
1,2,3a,4,5,9b-hexahydro-9b-(methoxycarbonylmethyl)naphtho<2,1-b>furan-2-one

: 95417-65-5
1-benzylspiro-2'-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 10percent KOH / 1.) MeOH, H₂O, reflux, 30 min; 2.) 180 deg C, 4 h

2: 59 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1248/cpb.32.3561