(1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol

Base Information

• Chemical Name: (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol
• CAS No.: 127492-57-3
• Molecular Formula: C₆₀H₁₁₈O₈S₂Si₃
• Molecular Weight: 1115.98
• Mol file: 127492-57-3.mol

Synonyms:

Chemical Property of (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol

There total 4 articles about (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C68H124O9S2Si3 (127492-56-2,127593-03-7) → (1E,9Z)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol (127492-57-3,127592-41-0) + (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol (127492-57-3,127592-41-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In isopropyl alcohol; acetonitrile; at 70 ℃; for 46h;

DOI:10.1021/jo00296a042

Reference yield: 33.0%

C68H124O9S2Si3 (127492-56-2,127593-03-7) → (1E,9Z)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol (127492-57-3,127592-41-0) + (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol (127492-57-3,127592-41-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In isopropyl alcohol; acetonitrile; at 70 ℃; for 46h;

DOI:10.1021/jo00296a042

Reference yield:

C76H129F3O13S3Si3 (127492-55-1) → (1E,9Z)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol (127492-57-3,127592-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Li naphthalenide / tetrahydrofuran / 10 h / -20 °C

2: 11 percent / pyridinium p-toluenesulfonate / propan-2-ol; acetonitrile / 46 h / 70 °C

With Li naphthalenide; pyridinium p-toluenesulfonate; In tetrahydrofuran; isopropyl alcohol; acetonitrile;

DOI:10.1021/jo00296a042

upstream raw materials:

C₆₈H₁₂₄O₉S₂Si₃

C₇₆H₁₂₉F₃O₁₃S₃Si₃

Downstream raw materials:

C₈₀H₁₅₅NO₁₁S₂Si₄

C₆₆H₁₃₂O₉Si₄

C₆₉H₁₃₈O₈S₂Si₄