hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

Base Information

Chemical Name:hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>
CAS No.:112924-59-1
Molecular Formula:C₁₇H₂₃NO₃
Molecular Weight:289.375
Hs Code.:

hexahydro-2-(3,4-dimethoxyphenyl)spiro<cyclopropane-1,2'-<2H>isoxazolo<2,3-a>pyridine>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

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Technology Process of hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

There total 3 articles about hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6380-23-0
3,4-dimethoxystyrene

: 112924-59-1
hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

Guidance literature:: Multi-step reaction with 3 steps

1: LiBr, 1.6 M BuLi / diethyl ether / -40 °C

2: 77 percent / t-BuOK / dimethylsulfoxide / 2 h / 90 °C

3: CH₂Cl₂ / 96 h / Ambient temperature

With n-butyllithium; potassium tert-butylate; lithium bromide; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00246a008

Reference yield:

: 112840-47-8
1-chloro-1-methyl-2-(3,4-dimethoxyphenyl)cyclopropane

: 112924-59-1
hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / t-BuOK / dimethylsulfoxide / 2 h / 90 °C

2: CH₂Cl₂ / 96 h / Ambient temperature

With potassium tert-butylate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00246a008

Reference yield:

: 34418-91-2
2,3,4,5-tetrahydropyridine N-oxide

: 112840-38-7
2-(3,4-dimethoxyphenyl)methylenecyclopropane

: 112840-39-8
hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

: 112924-59-1
hexahydro-2-(3,4-dimethoxyphenyl)spiroisoxazolo<2,3-a>pyridine>

Guidance literature:: In dichloromethane; for 96h; Yield given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jo00246a008