-(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide

Base Information

Chemical Name:-(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide
CAS No.:142840-12-8
Molecular Formula:C₁₄H₁₆N₂O₄
Molecular Weight:276.292
Hs Code.:

<R,S>-(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<e><1,2>oxazine N-oxide

Synonyms:

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Chemical Property of -(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide

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Technology Process of -(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide

There total 4 articles about -(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 4231-16-7
1-(p-nitrophenyl)-2-nitro-1-propene

: 142-29-0
cyclopentene

: 142840-12-8
-(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide

Guidance literature:: With tin(IV) chloride; In dichloromethane; for 7h; -78 deg C up to RT;
DOI:10.1021/jo00044a029

Reference yield:

: 142839-98-3,142839-99-4,14438-62-1
2-nitro-1-(4-nitrophenyl)propan-1-ol

: 142840-12-8
-(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / DMAP / diethyl ether / 3 h

2: 77 percent / DMAP / CH₂Cl₂ / 0.75 h

3: 38 percent / SnCl₄ / CH₂Cl₂ / 7 h / -78 deg C up to RT

With dmap; tin(IV) chloride; In diethyl ether; dichloromethane;
DOI:10.1021/jo00044a029

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 142840-12-8
-(3al,7l,7al)-1,2,3,3a,7,7a-hexahydro-6-methyl-7-(4-nitrophenyl)cyclopent<1,2>oxazine N-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran

2: 88 percent / DMAP / diethyl ether / 3 h

3: 77 percent / DMAP / CH₂Cl₂ / 0.75 h

4: 38 percent / SnCl₄ / CH₂Cl₂ / 7 h / -78 deg C up to RT

With dmap; potassium tert-butylate; tin(IV) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00044a029