H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH

Base Information

Chemical Name:H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH
CAS No.:131696-89-4
Molecular Formula:2C₂H₄O₂*C₃₂H₅₂N₈O₉
Molecular Weight:812.918
Hs Code.:

Synonyms:

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Chemical Property of H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH

Chemical Property:

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Technology Process of H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH

There total 11 articles about H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3350-19-4
(tert-butoxycarbonyl)-L-leucine p-nitrobenzylester

: 131696-89-4
H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent

2: 3.8 N HCl / dioxane

3: 79 percent

4: 3.8 N HCl / dioxane

5: 69 percent

6: 98 percent / catalytic hydrogenation

7: 1) methanesulfonic acid, thioanisole, m-cresol, 2) Amberlite IRA 45 (acetate form) / 1a) 0 deg C, 30 min, b) r.t., 90 min, 2) 30 min

With hydrogenchloride; methanesulfonic acid; methyl-phenyl-thioether; Amberlite IRA 45 (acetate form); 3-methyl-phenol; In 1,4-dioxane;
DOI:10.1248/cpb.38.2369

Reference yield:

: 58810-05-2
Z-Arg(Mts)-OH

: 131696-89-4
H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH

Guidance literature:: Multi-step reaction with 9 steps

1: 47.3 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / Ambient temperature

2: catalytic hydrogenation

3: 77 percent

4: 3.8 N HCl / dioxane

5: 79 percent

6: 3.8 N HCl / dioxane

7: 69 percent

8: 98 percent / catalytic hydrogenation

9: 1) methanesulfonic acid, thioanisole, m-cresol, 2) Amberlite IRA 45 (acetate form) / 1a) 0 deg C, 30 min, b) r.t., 90 min, 2) 30 min

With hydrogenchloride; methanesulfonic acid; methyl-phenyl-thioether; Amberlite IRA 45 (acetate form); diphenylphosphoranyl azide; 3-methyl-phenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2369

Reference yield:

: 3417-91-2
L-tyrosine methyl ester HCl

: 131696-89-4
H-Leu-Asp-Leu-Arg-Tyr-OMe*2AcOH

Guidance literature:: Multi-step reaction with 9 steps

1: 47.3 percent / diphenylphosphorylazide, NEt₃ / dimethylformamide / Ambient temperature

2: catalytic hydrogenation

3: 77 percent

4: 3.8 N HCl / dioxane

5: 79 percent

6: 3.8 N HCl / dioxane

7: 69 percent

8: 98 percent / catalytic hydrogenation

9: 1) methanesulfonic acid, thioanisole, m-cresol, 2) Amberlite IRA 45 (acetate form) / 1a) 0 deg C, 30 min, b) r.t., 90 min, 2) 30 min

With hydrogenchloride; methanesulfonic acid; methyl-phenyl-thioether; Amberlite IRA 45 (acetate form); diphenylphosphoranyl azide; 3-methyl-phenol; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2369