2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone

Base Information

• Chemical Name: 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone
• CAS No.: 199184-42-4
• Molecular Formula: C₂₆H₃₀O₄
• Molecular Weight: 406.522
• Mol file: 199184-42-4.mol

Synonyms:

Chemical Property of 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone

There total 1 articles about 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + (8R,9S,13S,14S,17S)-2-Dimethylaminomethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol (15410-29-4) → 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone (199184-42-4)

Guidance literature:

With sodium cyanide; Yield given. Multistep reaction; 1) DMF, 35 deg C, 30 min, 2) DMF, 100 deg C, 1 h;

DOI:10.1002/ardp.19973300906

Reference yield: 38.0%

4-(p-chlorophenyl)-3-thiosemicarbazide (22814-92-2) + 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone (199184-42-4) → C33H36ClN3O3S (199184-48-0)

Guidance literature:

With acetic acid; In ethanol; for 8h; Heating;

DOI:10.1002/ardp.19973300906

Reference yield: 33.0%

4-Phenyl-3-thiosemicarbazide (5351-69-9) + 2-((8R,9S,13S,14S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl)-1-(4-hydroxy-phenyl)-ethanone (199184-42-4) → C33H37N3O3S (199184-47-9)

Guidance literature:

With acetic acid; In ethanol; for 8h; Heating;

DOI:10.1002/ardp.19973300906

upstream raw materials:

4-hydroxy-benzaldehyde

(8R,9S,13S,14S,17S)-2-Dimethylaminomethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Downstream raw materials:

C₃₃H₃₆ClN₃O₃S

C₃₃H₃₇N₃O₃S