(1-deuterio-cyclohexyl)-p-tolyl sulfone

Base Information

• Chemical Name: (1-deuterio-cyclohexyl)-p-tolyl sulfone
• CAS No.: 106588-37-8
• Molecular Formula: C₁₃H₁₈O₂S
• Molecular Weight: 239.343
• Mol file: 106588-37-8.mol

Synonyms:

Chemical Property of (1-deuterio-cyclohexyl)-p-tolyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-deuterio-cyclohexyl)-p-tolyl sulfone

There total 4 articles about (1-deuterio-cyclohexyl)-p-tolyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(cyclohexylsulfonyl)-4-methylbenzene (67963-06-8) → (1-deuterio-cyclohexyl)-p-tolyl sulfone (106588-37-8)

Guidance literature:

With 1,4-dioxane; deuteriated sodium hydroxide; water-d2;

DOI:10.1021/ja01551a050

Reference yield:

1-bromocyclohexane (108-85-0) → (1-deuterio-cyclohexyl)-p-tolyl sulfone (106588-37-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aq.-ethanolic KOH

2: aqueous H₂O₂; acetic acid; acetic acid anhydride

3: methyl magnesium iodide; diethyl ether / anschliessend Erwaermen mit D₂O

With potassium hydroxide; methyl magnesium iodide; diethyl ether; dihydrogen peroxide; acetic anhydride; acetic acid;

DOI:10.1021/ja01551a050

Reference yield:

(4-methylphenyl)cyclohexyl sulfane (59693-93-5) → (1-deuterio-cyclohexyl)-p-tolyl sulfone (106588-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous H₂O₂; acetic acid; acetic acid anhydride

2: methyl magnesium iodide; diethyl ether / anschliessend Erwaermen mit D₂O

With methyl magnesium iodide; diethyl ether; dihydrogen peroxide; acetic anhydride; acetic acid;

DOI:10.1021/ja01551a050

upstream raw materials:

1-(cyclohexylsulfonyl)-4-methylbenzene

1-bromocyclohexane

(4-methylphenyl)cyclohexyl sulfane

para-thiocresol