(4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole

Base Information

Chemical Name:(4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole
CAS No.:89965-53-7
Molecular Formula:C₁₂H₁₃NO₄
Molecular Weight:235.24
Hs Code.:

Synonyms:

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Chemical Property of (4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole

Chemical Property:

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Technology Process of (4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole

There total 7 articles about (4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14389-86-7
2-benzyloxybenzoic acid

: 89965-53-7
(4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / dicyclohexylcarbodi-imide, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

2: 68 percent / Et₃N / tetrahydrofuran; H₂O / 240 h / Ambient temperature

3: 96 percent / diethyl ether

4: 76 percent / 90percent HCO₂H / 10percent Pd-C / methanol / 0.5 h

5: 1.) SOCl₂, 2.) anhyd. Na₂CO₃ / 1.) room temperature, 2 h, 2.) CHCl₃, room temperature, 1 h

With dmap; formic acid; thionyl chloride; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

Reference yield:

: 55142-16-0
methyl 2-(benzyloxy)benzoate

: 89965-53-7
(4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / LiOH / tetrahydrofuran; H₂O / Ambient temperature

2: 98 percent / dicyclohexylcarbodi-imide, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

3: 68 percent / Et₃N / tetrahydrofuran; H₂O / 240 h / Ambient temperature

4: 96 percent / diethyl ether

5: 76 percent / 90percent HCO₂H / 10percent Pd-C / methanol / 0.5 h

6: 1.) SOCl₂, 2.) anhyd. Na₂CO₃ / 1.) room temperature, 2 h, 2.) CHCl₃, room temperature, 1 h

With dmap; lithium hydroxide; formic acid; thionyl chloride; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;

Reference yield:

: 81254-81-1
3-(2-benzyloxybenzoyl)-1,3-thiazolidine-2-thione

: 89965-53-7
(4R,5R)-2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-methyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / Et₃N / tetrahydrofuran; H₂O / 240 h / Ambient temperature

2: 96 percent / diethyl ether

3: 76 percent / 90percent HCO₂H / 10percent Pd-C / methanol / 0.5 h

4: 1.) SOCl₂, 2.) anhyd. Na₂CO₃ / 1.) room temperature, 2 h, 2.) CHCl₃, room temperature, 1 h

With formic acid; thionyl chloride; sodium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water;