(+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)

Base Information

Chemical Name:(+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)
CAS No.:136282-42-3
Molecular Formula:C₆₃H₆₅O₁₄P₃
Molecular Weight:1139.12
Hs Code.:

Synonyms:

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Chemical Property of (+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)

Chemical Property:

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Technology Process of (+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)

There total 17 articles about (+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112204-05-4,149057-08-9
(+/-)-3,6-di-O-allyl-1,2-O-cyclohexylidene-myo-inositol

: 136282-42-3,138382-79-3,138382-80-6,145920-24-7,149056-99-5
(+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)

Guidance literature:: Multi-step reaction with 9 steps

1: 53 percent / tetrabutylammonium hydrogen sulfate, 5percent aq. NaOH / CH₂Cl₂ / 24 h / Heating

2: NaH / dimethylformamide / 2 h / 20 °C

3: HCl / methanol / 5 h / 20 °C

4: 95 percent / NaH / dimethylformamide / 2 h / 20 °C

5: (1,5-cyclooctadiene)bis(methyldiphenylphosphine)iridium hexafluorophosphate / 1,2-dichloro-ethane / 4 h

6: 92 percent / HCl / CH₂Cl₂; methanol / 1 h / 20 °C

7: 1) 1H-tetrazole, 2) tert-butyl hydroperoxide / 1) CH₂Cl₂, acetonitrile, 15 min., 2) 0 deg C, 45 min.

8: 82 percent / 2.5percent trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

9: 2) N-methylimidazole / 1) dioxane, 20 deg C, 30 min., 2) 20 deg C, 1 h

With 1-methyl-1H-imidazole; 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; trifluoroacetic acid; (1,5-cyclooctadiene)bis(methyldiphenylphosphine)iridium hexafluorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(92)85037-Z

Reference yield:

: 117666-29-2,145920-20-3,149056-92-8,149056-93-9
(+/-)-3,6-di-O-allyl-4-O-benzyl-1,2-O-cyclohexylidene-myo-inositol

: 136282-42-3,138382-79-3,138382-80-6,145920-24-7,149056-99-5
(+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)

Guidance literature:: Multi-step reaction with 8 steps

1: NaH / dimethylformamide / 2 h / 20 °C

2: HCl / methanol / 5 h / 20 °C

3: 95 percent / NaH / dimethylformamide / 2 h / 20 °C

4: (1,5-cyclooctadiene)bis(methyldiphenylphosphine)iridium hexafluorophosphate / 1,2-dichloro-ethane / 4 h

5: 92 percent / HCl / CH₂Cl₂; methanol / 1 h / 20 °C

6: 1) 1H-tetrazole, 2) tert-butyl hydroperoxide / 1) CH₂Cl₂, acetonitrile, 15 min., 2) 0 deg C, 45 min.

7: 82 percent / 2.5percent trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

8: 2) N-methylimidazole / 1) dioxane, 20 deg C, 30 min., 2) 20 deg C, 1 h

With 1-methyl-1H-imidazole; 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; sodium hydride; trifluoroacetic acid; (1,5-cyclooctadiene)bis(methyldiphenylphosphine)iridium hexafluorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(92)85037-Z

Reference yield:

: 138328-97-9,149056-95-1
(+/-)-1,4-di-O-allyl-2,3,6-tri-O-benzyl-5-O-p-methoxybenzyl-myo-inositol

: 136282-42-3,138382-79-3,138382-80-6,145920-24-7,149056-99-5
(+/-)-2,3,6-tri-O-benzyl-myo-inositol 5-(benzyl methylphosphonate) 1,4-bis(dibenzyl phosphate)

Guidance literature:: Multi-step reaction with 5 steps

1: (1,5-cyclooctadiene)bis(methyldiphenylphosphine)iridium hexafluorophosphate / 1,2-dichloro-ethane / 4 h

2: 92 percent / HCl / CH₂Cl₂; methanol / 1 h / 20 °C

3: 1) 1H-tetrazole, 2) tert-butyl hydroperoxide / 1) CH₂Cl₂, acetonitrile, 15 min., 2) 0 deg C, 45 min.

4: 82 percent / 2.5percent trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

5: 2) N-methylimidazole / 1) dioxane, 20 deg C, 30 min., 2) 20 deg C, 1 h

With 1-methyl-1H-imidazole; 1H-tetrazole; hydrogenchloride; tert.-butylhydroperoxide; trifluoroacetic acid; (1,5-cyclooctadiene)bis(methyldiphenylphosphine)iridium hexafluorophosphate; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/0008-6215(92)85037-Z