4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate

Base Information

Chemical Name:4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate
CAS No.:1217508-83-2
Molecular Formula:C₅₁H₈₃FN₄O₁₅
Molecular Weight:1011.24
Hs Code.:

Synonyms:

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Chemical Property of 4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate

Chemical Property:

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Technology Process of 4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate

There total 5 articles about 4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951662-62-7
C₁₆H₂₃FN₂O₃

: 1217508-83-2
4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; ethyl acetate / 12 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 20 °C

3: methanol / 24 h / 55 °C

With hydrogenchloride; methanol; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1038/ja.2009.108

Reference yield:

: 83905-02-6
(2S,3R,4S,6R)-4-(dimethylamino)-2-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl)oxy)-6-methyltetrahydro-2H-pyran-3-yl acetate

: 1217508-83-2
4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / toluene / 24 h / 75 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 20 °C

3: methanol / 24 h / 55 °C

With methanol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1038/ja.2009.108

Reference yield:

: 83905-01-5,92470-27-4
Zithromax(R)

: 1217508-83-2
4-O-(((4-fluorobenzyl)amino)-4-oxobutyl)carbamoylazithromycin 11,12-cyclic carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 12 h / 20 °C

2: triethylamine / toluene / 24 h / 75 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 10 h / 20 °C

4: methanol / 24 h / 55 °C

With methanol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1038/ja.2009.108