3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione

Base Information

• Chemical Name: 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione
• CAS No.: 79496-53-0
• Molecular Formula: C₁₈H₃₀N₂O₅S
• Molecular Weight: 386.513
• Mol file: 79496-53-0.mol

Synonyms:

Chemical Property of 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione

There total 5 articles about 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(6-t-butyloxycarbonylhexyl)-1,3,4-thiadiazolidine-2,5-dione (79496-54-1) → 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione (79496-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: benzyltrimethylammonium hydroxide / dioxane / 4 h / Heating

2: sodium borohydride / dioxane; ethanol / 5 h / Ambient temperature

3: 1.) trifluoroacetic acid, 2.) 5percent sodium hydrogencarbonate / 1.) 0 deg C, 1.5 h, 2.) water, 1 h

With sodium tetrahydroborate; N-benzyl-trimethylammonium hydroxide; sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; ethanol;

DOI:10.1039/P19810002096

Reference yield:

7-bromoheptanoic acid t-butyl ester (51100-47-1) → 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione (79496-53-0)

Guidance literature:

Multi-step reaction with 4 steps

2: benzyltrimethylammonium hydroxide / dioxane / 4 h / Heating

3: sodium borohydride / dioxane; ethanol / 5 h / Ambient temperature

4: 1.) trifluoroacetic acid, 2.) 5percent sodium hydrogencarbonate / 1.) 0 deg C, 1.5 h, 2.) water, 1 h

With sodium tetrahydroborate; N-benzyl-trimethylammonium hydroxide; sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; ethanol;

DOI:10.1039/P19810002096

Reference yield:

1-cyclohexylprop-2-en-1-one (2177-34-6) → 3-(6-carboxyhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione (79496-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: benzyltrimethylammonium hydroxide / dioxane / 4 h / Heating

2: sodium borohydride / dioxane; ethanol / 5 h / Ambient temperature

3: 1.) trifluoroacetic acid, 2.) 5percent sodium hydrogencarbonate / 1.) 0 deg C, 1.5 h, 2.) water, 1 h

With sodium tetrahydroborate; N-benzyl-trimethylammonium hydroxide; sodium hydrogencarbonate; trifluoroacetic acid; In 1,4-dioxane; ethanol;

DOI:10.1039/P19810002096

upstream raw materials:

3-(6-t-butyloxycarbonylhexyl)-4-(3-cyclohexyl-3-hydroxypropyl)-1,3,4-thiadiazolidine-2,5-dione

3-(6-t-butyloxycarbonylhexyl)-1,3,4-thiadiazolidine-2,5-dione

7-bromoheptanoic acid t-butyl ester

1-cyclohexylprop-2-en-1-one