(4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aβ-hexahydro-7-methoxy-1-methylphenanthrene

Base Information

Chemical Name:(4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aβ-hexahydro-7-methoxy-1-methylphenanthrene
CAS No.:115522-94-6
Molecular Formula:C₂₄H₂₉NO
Molecular Weight:347.5
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aβ-hexahydro-7-methoxy-1-methylphenanthrene

Chemical Property:

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Technology Process of (4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aβ-hexahydro-7-methoxy-1-methylphenanthrene

There total 25 articles about (4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aβ-hexahydro-7-methoxy-1-methylphenanthrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115171-41-0
2-ethoxycarbonyloxy-3,4-dihydro-6-methoxy-1-methyl-naphthalene

: 115522-94-6
(4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aα-hexahydro-7-methoxy-1-methylphenanthrene

Guidance literature:: Multi-step reaction with 12 steps

1: NaIO₄ / OsO₄ / diethyl ether; H₂O

2: p-MeC₆H₄SO₃H

3: 1.) ZnI₂; 2.) POCl₃, pyridine

4: DIBAL-H

5: benzene

6: DIBAL-H / tetrahydrofuran

7: pyridinium dichromate / CH₂Cl₂

8: diethyl ether

9: 86 percent / MeSO₂Cl, Et₃N / CH₂Cl₂ / -78 - 25 °C

10: LiAlH₄ / tetrahydrofuran; diethyl ether

11: K₂CO₃ / tetrahydrofuran; diethyl ether

12: LiAlH₄ / tetrahydrofuran

With pyridine; sodium periodate; lithium aluminium tetrahydride; dipyridinium dichromate; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; zinc(II) iodide; trichlorophosphate; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; benzene;
DOI:10.1039/c39870001360

Reference yield:

: 115171-41-0
2-ethoxycarbonyloxy-3,4-dihydro-6-methoxy-1-methyl-naphthalene

: 115522-94-6
(4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aβ-hexahydro-7-methoxy-1-methylphenanthrene

Guidance literature:: Multi-step reaction with 12 steps

1: NaIO₄ / OsO₄ / diethyl ether; H₂O

2: p-MeC₆H₄SO₃H

3: 1.) ZnI₂; 2.) POCl₃, pyridine

4: DIBAL-H

5: benzene

6: DIBAL-H / tetrahydrofuran

7: pyridinium dichromate / CH₂Cl₂

8: diethyl ether

9: 86 percent / MeSO₂Cl, Et₃N / CH₂Cl₂ / -78 - 25 °C

10: LiAlH₄ / tetrahydrofuran; diethyl ether

11: K₂CO₃ / tetrahydrofuran; diethyl ether

12: LiAlH₄ / tetrahydrofuran

With pyridine; sodium periodate; lithium aluminium tetrahydride; dipyridinium dichromate; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; methanesulfonyl chloride; triethylamine; zinc(II) iodide; trichlorophosphate; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; benzene;
DOI:10.1039/c39870001360

Reference yield:

: 115522-92-4,115522-93-5
(4aS*)-4aα-(benzamidomethyl)-3,4,4a,9,10,10aα-hexahydro-7-methoxy-1-methylphenanthrene

: 115522-94-6
(4aS*)-4aα-(N-benzylaminomethyl)-3,4,4a,9,10,10aα-hexahydro-7-methoxy-1-methylphenanthrene

Guidance literature:: With lithium aluminium tetrahydride; water; Yield given. Multistep reaction; 1) THF, reflux, 4 h, 2) THF, ether, 0 deg C;