N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine

Base Information

• Chemical Name: N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine
• CAS No.: 173605-89-5
• Molecular Formula: C₃₉H₄₅N₃O₄
• Molecular Weight: 619.804
• Mol file: 173605-89-5.mol

Synonyms:

Chemical Property of N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine

There total 9 articles about N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S)-3-amino-4,4-diphenyl-1-butanol (158530-69-9) → N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine (173605-89-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 70 percent / acetic acid / 0.67 h / 80 °C

2: 71 percent / pyridine / 2 h / 0 °C

3: 70 percent / NaHCO₃ / acetonitrile / 48 h / 70 °C

4: 70 percent / HCOONH₄ / 10percent Pd/C / methanol / 2.5 h / Heating

5: tetrahydrofuran / a) 0 deg C, 30 min, b) RT, overnight

6: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, 5 min, 2.) CH₂Cl₂, MeOH, 0 deg C

With pyridine; sodium tetrahydroborate; ammonium formate; sodium hydrogencarbonate; ozone; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; acetonitrile;

DOI:10.1016/0957-4166(95)00374-X

Reference yield:

(S)-1,1-diphenyl-2-(1-pyrrolyl)-butan-4-ol (158530-70-2) → N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine (173605-89-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 71 percent / pyridine / 2 h / 0 °C

2: 70 percent / NaHCO₃ / acetonitrile / 48 h / 70 °C

3: 70 percent / HCOONH₄ / 10percent Pd/C / methanol / 2.5 h / Heating

4: tetrahydrofuran / a) 0 deg C, 30 min, b) RT, overnight

5: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, 5 min, 2.) CH₂Cl₂, MeOH, 0 deg C

With pyridine; sodium tetrahydroborate; ammonium formate; sodium hydrogencarbonate; ozone; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/0957-4166(95)00374-X

Reference yield:

N-benzyl-N,N-bis<(S)-4,4-diphenyl-3-(1-pyrrolyl)-butyl>amine (158530-71-3) → N-tert-butoxycarbonyl-N,N-bis<(S)-4,4-diphenyl-3-formamidobutyl>amine (173605-89-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / HCOONH₄ / 10percent Pd/C / methanol / 2.5 h / Heating

2: tetrahydrofuran / a) 0 deg C, 30 min, b) RT, overnight

3: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, 5 min, 2.) CH₂Cl₂, MeOH, 0 deg C

With sodium tetrahydroborate; ammonium formate; ozone; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1016/0957-4166(95)00374-X

upstream raw materials:

di-tert-butyl dicarbonate

N-benzyl-N,N-bis<(S)-4,4-diphenyl-3-(1-pyrrolyl)-butyl>amine

Bis-((S)-4,4-diphenyl-3-pyrrol-1-yl-butyl)-carbamic acid tert-butyl ester

(3S)-3-amino-4,4-diphenyl-1-butanol

Downstream raw materials:

(S)-N¹-((S)-3-Amino-4,4-diphenyl-butyl)-4,4-diphenyl-butane-1,3-diamine