5-n-butyl-2-chloroacetophenone

Base Information

• Chemical Name: 5-n-butyl-2-chloroacetophenone
• CAS No.: 86309-07-1
• Molecular Formula: C₁₂H₁₅ClO
• Molecular Weight: 210.704
• Mol file: 86309-07-1.mol

Synonyms:

Chemical Property of 5-n-butyl-2-chloroacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-n-butyl-2-chloroacetophenone

There total 5 articles about 5-n-butyl-2-chloroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-n-butanoylchlorobenzene (4981-63-9) → 5-n-butyl-2-chloroacetophenone (86309-07-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / HNO₃ / -15 °C

2: 81 percent / zinc, ammonium chloride / ethanol; H₂O / 2 h / Heating

3: 70.5 percent / potassium hydroxide, hydrazine hydrate / various solvent(s) / 4 h / 195 °C

4: 1.) sodium nitrite, aq. HCl, 2.) cupric sulfate, sodium sulfate, sodium acetate, 3.) concd. HCl / 1.) 0-5 deg C, 2.) 1 h, 3.) H₂O, reflux, 3 h

With hydrogenchloride; potassium hydroxide; ammonium chloride; nitric acid; sodium acetate; hydrazine hydrate; copper(II) sulfate; sodium sulfate; zinc; sodium nitrite; In ethanol; water;

DOI:10.1021/jm00364a004

Reference yield:

2-amino-4-n-butanoylchlorobenzene (2001-00-5) → 5-n-butyl-2-chloroacetophenone (86309-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70.5 percent / potassium hydroxide, hydrazine hydrate / various solvent(s) / 4 h / 195 °C

2: 1.) sodium nitrite, aq. HCl, 2.) cupric sulfate, sodium sulfate, sodium acetate, 3.) concd. HCl / 1.) 0-5 deg C, 2.) 1 h, 3.) H₂O, reflux, 3 h

With hydrogenchloride; potassium hydroxide; sodium acetate; hydrazine hydrate; copper(II) sulfate; sodium sulfate; sodium nitrite; In various solvent(s);

DOI:10.1021/jm00364a004

Reference yield:

4-n-butanoyl-2-nitrochlorobenzene (66353-38-6) → 5-n-butyl-2-chloroacetophenone (86309-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / zinc, ammonium chloride / ethanol; H₂O / 2 h / Heating

2: 70.5 percent / potassium hydroxide, hydrazine hydrate / various solvent(s) / 4 h / 195 °C

3: 1.) sodium nitrite, aq. HCl, 2.) cupric sulfate, sodium sulfate, sodium acetate, 3.) concd. HCl / 1.) 0-5 deg C, 2.) 1 h, 3.) H₂O, reflux, 3 h

With hydrogenchloride; potassium hydroxide; ammonium chloride; sodium acetate; hydrazine hydrate; copper(II) sulfate; sodium sulfate; zinc; sodium nitrite; In ethanol; water;

DOI:10.1021/jm00364a004

upstream raw materials:

Acetaldehyde oxime

2-amino-4-n-butylchlorobenzene

4-n-butanoylchlorobenzene

2-amino-4-n-butanoylchlorobenzene

Downstream raw materials:

[5-Butyl-2-(2-chloro-4-methyl-phenoxy)-phenyl]-acetic acid