2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine

Base Information

• Chemical Name: 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine
• CAS No.: 117856-53-8
• Molecular Formula: C₂₆H₄₆N₂O₅SSi₂
• Molecular Weight: 554.899
• Mol file: 117856-53-8.mol

Synonyms:

Chemical Property of 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine

There total 8 articles about 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2,5-dimethoxy-3,6-dihydropyrazine (117856-49-2) → 2,5-dimethoxypyrazine (117856-61-8) + 1-(dimethyl-t-butylsilyloxy)-3-trimethylsilyl-4-(p-tolylsulphonyl)butane (117856-55-0) + 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine (117856-53-8,117856-54-9)

Guidance literature:

With Z-⁽²⁷⁾; lithium dicyclohexylamide; In tetrahydrofuran; at -40 ℃; for 72h;

Reference yield: 21.0%

(1Z)-4-(dimethyl-t-butylsilyloxy)-2-trimethylsilyl-1-(p-tolylsulphonyl)but-1-ene (104124-05-2) → 2,5-dimethoxypyrazine (117856-61-8) + 1-(dimethyl-t-butylsilyloxy)-3-trimethylsilyl-4-(p-tolylsulphonyl)butane (117856-55-0) + 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine (117856-53-8,117856-54-9)

Guidance literature:

With bis imino ether ⁽¹⁸⁾; lithium dicyclohexylamide; In tetrahydrofuran; at -40 ℃; for 72h;

Reference yield: 21.0%

2,5-dimethoxy-3,6-dihydropyrazine (117856-49-2) + (1Z)-4-(dimethyl-t-butylsilyloxy)-2-trimethylsilyl-1-(p-tolylsulphonyl)but-1-ene (104124-05-2) → 2,5-dimethoxypyrazine (117856-61-8) + 1-(dimethyl-t-butylsilyloxy)-3-trimethylsilyl-4-(p-tolylsulphonyl)butane (117856-55-0) + 2-[3-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonylmethyl)-1-trimethylsilanyl-propyl]-3,6-dimethoxy-2,5-dihydro-pyrazine (117856-53-8,117856-54-9)

Guidance literature:

With lithium dicyclohexylamide; In tetrahydrofuran; at -40 ℃; for 72h;

upstream raw materials:

2,5-dimethoxy-3,6-dihydropyrazine

(1Z)-4-(dimethyl-t-butylsilyloxy)-2-trimethylsilyl-1-(p-tolylsulphonyl)but-1-ene

1-bromo-1-(trimethylsilyl)ethene

3-trimethylsilylbut-3-en-1-ol