1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one

Base Information

• Chemical Name: 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one
• CAS No.: 81454-39-9
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.45

Synonyms:

Chemical Property of 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one

There total 7 articles about 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylpyridine (1122-62-9) → 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one (81454-39-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 37 percent / NH₄Cl / methanol / 60 h / Heating

2: 92 percent / H₂ / PtO₂ / methanol / 20.5 h / 25 °C / 3102.9 Torr

3: (i-Pr)2NEt / CH₂Cl₂ / 1.) 0-5 deg C, 1-2 h, 2.) 25 deg C, overnight

4: 27 percent / HCl / tetrahydrofuran; H₂O / 2.5 h / 33 °C

5: benzene / Heating

With hydrogenchloride; hydrogen; ammonium chloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; benzene;

DOI:10.1016/S0040-4020(01)98890-8

Reference yield:

2-(1,1-dimethoxyethyl)-pyridine (81454-23-1) → 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one (81454-39-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / H₂ / PtO₂ / methanol / 20.5 h / 25 °C / 3102.9 Torr

2: (i-Pr)2NEt / CH₂Cl₂ / 1.) 0-5 deg C, 1-2 h, 2.) 25 deg C, overnight

3: 27 percent / HCl / tetrahydrofuran; H₂O / 2.5 h / 33 °C

4: benzene / Heating

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; benzene;

DOI:10.1016/S0040-4020(01)98890-8

Reference yield:

1,4-dihydrobenzoic acid (4794-04-1) → 1-benzyl-11bβ-methyl-2aβ,3,5aβ,8,9,10,11,11aα,11b,11cβ-decahydro-2H-isoxazolo <5,4,3-k,l> benzo quinolizin-6-one (81454-39-9)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexylcarbodimide / CH₂Cl₂ / 25 °C

2: (i-Pr)2NEt / CH₂Cl₂ / 1.) 0-5 deg C, 1-2 h, 2.) 25 deg C, overnight

3: 27 percent / HCl / tetrahydrofuran; H₂O / 2.5 h / 33 °C

4: benzene / Heating

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; benzene;

DOI:10.1016/S0040-4020(01)98890-8

upstream raw materials:

2-acetylpiperidine 1,4-dihydrobenzamide

N-benzyl hydroxylalmine

2-acetylpyridine

1,4-dihydrobenzoic acid

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