(3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

Base Information

Chemical Name:(3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione
CAS No.:106367-83-3
Molecular Formula:C₃₂H₃₂N₂O₃S₃
Molecular Weight:588.816
Hs Code.:

(3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

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Chemical Property of (3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

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Technology Process of (3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

There total 1 articles about (3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85924-17-0
(+/-)-2,3-didehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-phenylthio-aspidospermidin-10-one

: 106367-83-3
(3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

Guidance literature:: With Lawessons reagent; In toluene; at 80 ℃; for 1h;
DOI:10.1016/S0040-4020(01)87386-5

Reference yield:

: 106367-83-3
(3aR,10bR,11R,12bR)-3a-Ethyl-6-(4-methoxy-benzenesulfonyl)-11-phenylsulfanyl-2,3,3a,4,6,12b-hexahydro-1H-6,12a-diaza-indeno[7,1-cd]fluorene-12-thione

: 106367-81-1
(+/-)-1-<(p-methoxyphenyl)sulfonyl>-2β-hydroxy-3β-(3-chlorobenzoyloxy)-aspidospermadine

Guidance literature:: Multi-step reaction with 3 steps

1: 77.5 mg / Raney nickel / ethanol; tetrahydrofuran / 0.75 h

2: CH₂Cl₂; benzene / 22 h / 20 °C

3: 36.5 percent / PPh₃ / acetic acid; H₂O / 72 h / 20 °C

With triphenylphosphine; nickel; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; benzene;
DOI:10.1016/S0040-4020(01)87386-5