IverMectin B1 Mono-sugar Derivative

Base Information

• Chemical Name: IverMectin B1 Mono-sugar Derivative
• CAS No.: 71837-27-9
• Molecular Formula: C₄₁H₆₂O₁₁
• Molecular Weight: 730.937
• Mol file: 71837-27-9.mol

Synonyms:

Chemical Property of IverMectin B1 Mono-sugar Derivative

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

IvermectinB1Monosaccharide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ivermectin B1 Mono-sugar Derivative is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.

Technology Process of IverMectin B1 Mono-sugar Derivative

There total 2 articles about IverMectin B1 Mono-sugar Derivative which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-O-demethyl-22,23-dihydro-avermectin A1a (71827-03-7) → ivermectin aglycone (73162-95-5) + 22,23-Dihydroavermectin B1a monosaccharide (71837-27-9)

Guidance literature:

With sulfuric acid; water;

Reference yield: 48.0%

5-O-demethyl-22,23-dihydro-avermectin A1a (71827-03-7) → C40H60O11 + ivermectin aglycone (73162-95-5) + 22,23-Dihydroavermectin B1a monosaccharide (71837-27-9)

Guidance literature:

With sulfuric acid; In isopropyl alcohol; at 20 ℃; for 6h;

DOI:10.1021/ja065950k

Reference yield:

22,23-Dihydroavermectin B1a monosaccharide (71837-27-9) → C48H66ClNO12 (1258313-50-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 20 °C

2: dmap / dichloromethane / 20 °C

3: toluene-4-sulfonic acid / methanol / 20 °C

With 1H-imidazole; dmap; toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1016/j.cclet.2010.06.035

upstream raw materials:

5-O-demethyl-22,23-dihydro-avermectin A₁a

Downstream raw materials:

C₄₈H₆₇NO₁₂

C₄₈H₆₆ClNO₁₂

C₄₈H₆₆ClNO₁₂

C₄₉H₆₉NO₁₂