2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate

Base Information

Chemical Name:2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate
CAS No.:33493-07-1
Molecular Formula:C₇H₈O₃S*C₁₁H₁₃Cl₃N₂O₃S₂
Molecular Weight:563.932
Hs Code.:

Synonyms:

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Chemical Property of 2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate

Chemical Property:

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Technology Process of 2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate

There total 6 articles about 2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24689-52-9
2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

: 33493-07-1
2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate

Guidance literature:: Multi-step reaction with 4 steps

1: NBS / 1,2-dichloro-ethane / 1.42 h / -10 °C / Irradiation

2: 61.8 percent / NEt₃ / dimethylformamide / 1 h / -20 - 25 °C

3: 95 percent / KI, acetyl chloride / dimethylformamide / 0.17 h / 26 °C

4: 1.) PCl₅, pyridine / 1.) CH₂Cl₂, -20 deg C - 18 deg C; 2.) MeOH/ether, -15 deg C, 2 h

With pyridine; N-Bromosuccinimide; phosphorus pentachloride; triethylamine; acetyl chloride; potassium iodide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91829-0

Reference yield:

: 24647-47-0
2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

: 33493-07-1
2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 62.6 percent / peracetic acid / CH₂Cl₂ / 0.05 h / 20 - 30 °C

2: NBS / 1,2-dichloro-ethane / 1.42 h / -10 °C / Irradiation

3: 61.8 percent / NEt₃ / dimethylformamide / 1 h / -20 - 25 °C

4: 95 percent / KI, acetyl chloride / dimethylformamide / 0.17 h / 26 °C

5: 1.) PCl₅, pyridine / 1.) CH₂Cl₂, -20 deg C - 18 deg C; 2.) MeOH/ether, -15 deg C, 2 h

With pyridine; peracetic acid; N-Bromosuccinimide; phosphorus pentachloride; triethylamine; acetyl chloride; potassium iodide; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91829-0

Reference yield:

: 33493-13-9
2,2,2-trichloroethyl(1S,6R,7R)-3-methylthiomethyl-7-phenoxyacetamidoceph-3-em-4-carboxylate 1-oxide

: 33493-07-1
2,2,2-trichloroethyl(6R,7R)-7-amino-3-methylthiomethyl-ceph-3-em-4-carboxylate hydrogen toluene-4-sulphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / KI, acetyl chloride / dimethylformamide / 0.17 h / 26 °C

2: 1.) PCl₅, pyridine / 1.) CH₂Cl₂, -20 deg C - 18 deg C; 2.) MeOH/ether, -15 deg C, 2 h

With pyridine; phosphorus pentachloride; acetyl chloride; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91829-0