Technology Process of <2R-(2α(S*,R*),3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-2-<2,3,4-tris(phenylmethoxy)butoxy>-4,7-methanobenzofuran
There total 11 articles about <2R-(2α(S*,R*),3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-2-<2,3,4-tris(phenylmethoxy)butoxy>-4,7-methanobenzofuran which
guide to synthetic route it.
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synthetic route:
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120786-31-4
<2R-(2α(S*,R*),3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-2-<2,3,4-tris(phenylmethoxy)butoxy>-4,7-methanobenzofuran
- Guidance literature:
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Multi-step reaction with 5 steps
1: 75 percent / dicyclohexylcarbodiimide, pyridine, phosphoric acid / benzene; dimethylsulfoxide / 3 h / Ambient temperature
2: 1) triethylamine, 2) NaBH4 / 1) room temp.; 2) MeOH, 50 deg C, 84 h
3: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) 2 h, room temp.
4: 56 percent / p-TsOH / CH2Cl2 / 2 h
5: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) room temp., 2 h
With
pyridine; sodium tetrahydroborate; phosphoric acid; sodium hydride; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide;
In
dichloromethane; dimethyl sulfoxide; benzene;
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120786-31-4
<2R-(2α(S*,R*),3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-2-<2,3,4-tris(phenylmethoxy)butoxy>-4,7-methanobenzofuran
- Guidance literature:
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Multi-step reaction with 4 steps
1: 1) triethylamine, 2) NaBH4 / 1) room temp.; 2) MeOH, 50 deg C, 84 h
2: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) 2 h, room temp.
3: 56 percent / p-TsOH / CH2Cl2 / 2 h
4: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) room temp., 2 h
With
sodium tetrahydroborate; sodium hydride; toluene-4-sulfonic acid; triethylamine;
In
dichloromethane;
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120786-31-4
<2R-(2α(S*,R*),3aα,4β,7β,7aα)>-Octahydro-7,8,8-trimethyl-2-<2,3,4-tris(phenylmethoxy)butoxy>-4,7-methanobenzofuran
- Guidance literature:
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Multi-step reaction with 5 steps
1: 70 percent / DIBAH / hexane; toluene / 2 h / -25 °C
2: 1) triethylamine, 2) NaBH4 / 1) room temp.; 2) MeOH, 50 deg C, 84 h
3: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) 2 h, room temp.
4: 56 percent / p-TsOH / CH2Cl2 / 2 h
5: 1) NaH / 1) DMF, -15 grad C, 1 h; 2) room temp., 2 h
With
sodium tetrahydroborate; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine;
In
hexane; dichloromethane; toluene;
