2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester

Base Information

• Chemical Name: 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester
• CAS No.: 1026892-45-4
• Molecular Formula: C₂₈H₃₆O₁₁
• Molecular Weight: 548.587
• Mol file: 1026892-45-4.mol

Synonyms:

Chemical Property of 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester

There total 4 articles about 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) + 2-[1-(2,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester (367248-68-8) → 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester (1026892-45-4)

Guidance literature:

2-[1-(2,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.166667h;

asaraldehyde; In tetrahydrofuran; at -70 ℃; for 1h;

DOI:10.1055/s-2001-16086

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester (1026892-45-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaOEt / ethanol / 21 h / Heating

2.1: 3.16 g / K₂CO₃ / acetone / 20 h / Heating

3.1: LDA / tetrahydrofuran / 0.17 h / -70 °C

3.2: tetrahydrofuran / 1 h / -70 °C

With sodium ethanolate; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; acetone; 1.1: Stobbe condensation;

DOI:10.1055/s-2001-16086

Reference yield:

(E)-3-ethoxycarbonyl-4-(2,4,5-trimethoxyphenyl)but-3-enoic acid (367248-67-7) → 2-[Hydroxy-(2,4,5-trimethoxy-phenyl)-methyl]-3-[1-(2,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester (1026892-45-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3.16 g / K₂CO₃ / acetone / 20 h / Heating

2.1: LDA / tetrahydrofuran / 0.17 h / -70 °C

2.2: tetrahydrofuran / 1 h / -70 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetone;

DOI:10.1055/s-2001-16086

upstream raw materials:

asaraldehyde

2-[1-(2,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-succinic acid diethyl ester

(E)-3-ethoxycarbonyl-4-(2,4,5-trimethoxyphenyl)but-3-enoic acid

succinic acid diethyl ester

Downstream raw materials:

magnoshinin