(2RS,3SR)-3-<amino>-2-(1-ethoxyethoxy)-3-phenylpropanoic acid

Base Information

• Chemical Name: (2RS,3SR)-3-<amino>-2-(1-ethoxyethoxy)-3-phenylpropanoic acid
• CAS No.: 136778-70-6
• Molecular Formula: C₁₈H₂₇NO₆
• Molecular Weight: 353.415
• Mol file: 136778-70-6.mol

Synonyms:

Chemical Property of (2RS,3SR)-3-<amino>-2-(1-ethoxyethoxy)-3-phenylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2RS,3SR)-3-<amino>-2-(1-ethoxyethoxy)-3-phenylpropanoic acid

There total 2 articles about (2RS,3SR)-3-<amino>-2-(1-ethoxyethoxy)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,1-dimethylethyl (N-((1S,2S)-2-(1-ethoxyethoxy)-1-phenyl-3-butenyl)amino)methanoate (136693-05-5,136778-74-0,139345-91-8,139345-92-9,145514-63-2,145514-65-4) → (2R,3S)-(+)-3-(N-(1,1-dimethylethoxycarbonyl)amino)-2-(1-ethoxyethoxy)-3-phenylpropanoic acid (126150-55-8,136778-68-2,136778-70-6,139345-93-0,139345-94-1,145514-64-3,145514-66-5)

Guidance literature:

With sodium periodate; sodium hydrogencarbonate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; for 48h; Ambient temperature;

DOI:10.1021/jo00024a044

Reference yield: 77.0%

[(1S,2S)-2-(1-Ethoxy-ethoxy)-1-phenyl-but-3-enyl]-carbamic acid tert-butyl ester (136693-05-5,136778-74-0,139345-91-8,139345-92-9,145514-63-2,145514-65-4) → (2RS,3SR)-3-<amino>-2-(1-ethoxyethoxy)-3-phenylpropanoic acid (126150-55-8,136778-68-2,136778-70-6,139345-93-0,139345-94-1,145514-64-3,145514-66-5)

Guidance literature:

With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 48h;

DOI:10.1021/jo00053a048

upstream raw materials:

1,1-dimethylethyl (N-((1S,2S)-2-(1-ethoxyethoxy)-1-phenyl-3-butenyl)amino)methanoate

[(1S,2S)-2-(1-Ethoxy-ethoxy)-1-phenyl-but-3-enyl]-carbamic acid tert-butyl ester