D-HIS-PROTIRELIN

Base Information

• Chemical Name: D-HIS-PROTIRELIN
• CAS No.: 40600-90-6
• Molecular Formula: C₁₆H₂₂N₆O₄
• Molecular Weight: 362.388
• Mol file: 40600-90-6.mol

Synonyms:

Chemical Property of D-HIS-PROTIRELIN

Chemical Property:

• Boiling Point: 978.4±65.0 °C(Predicted)
• PKA: 13.05±0.20(Predicted)
• Density: 1.421±0.06 g/cm3(Predicted)

Purity/Quality:

>95% ^*data from raw suppliers

D-His-Protirelin European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Oxo-L-prolyl-D-histidyl-L-prolinamide is used in the solid phase or solution synthesis of TRH peptides as CNS active TSH-releasing hormone analogs.

Technology Process of D-HIS-PROTIRELIN

There total 5 articles about D-HIS-PROTIRELIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Z-L-pGlu-L-His(CH2Ph)-L-Pro-NH2 (32926-30-0) → L-pGlu-L-His-L-Pro-NH2 (24305-27-9,40600-90-6,40600-91-7,50894-60-5,50894-61-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 3040 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)91381-X

Reference yield:

→ Pyroglutamylhistidylprolinamid (24305-27-9,40600-90-6,40600-91-7,50894-60-5,50894-61-6)

Guidance literature:

Glu-His-Pro-NH2, HOAc/erhitzen;

Reference yield:

→ Pyroglutamylhistidylprolinamid (TRF) (24305-27-9,40600-90-6,40600-91-7,50894-60-5,50894-61-6)

Guidance literature:

t.-Butyloxicarbonyl-pyroglutamylhistidyl-prolyldehehydroalaninharz (1d);

upstream raw materials:

Z-L-pGlu-L-His(CH₂Ph)-L-Pro-NH₂

dicyclohexylamine salt of N-benzyloxycarbonyl-(L)-pyroglutamic acid

L-His(CH₂Ph)-L-Pro-NH₂