{(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:97995-52-3
Molecular Formula:C₄₀H₅₆F₂N₈O₇
Molecular Weight:798.931
Hs Code.:

{(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 22 articles about {(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₇H₆₂F₂N₈O₉S

: 97995-52-3
{(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; In methanol; for 14h; Ambient temperature;
DOI:10.1021/jm00160a048

Reference yield:

: 97995-51-2
C₄₇H₆₂F₂N₈O₉S

: 97995-52-3
{(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; In methanol;
DOI:10.1021/jm00149a001

Reference yield:

: 58521-45-2
tert-butoxycarbonyl-L-leucinal

: 97995-52-3
{(S)-1-[(S)-1-[(S)-1-((S)-2,2-Difluoro-1-hydroxy-2-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-ethyl)-3-methyl-butylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: Zn / tetrahydrofuran / Ambient temperature; Irradiation

2: NaOH / tetrahydrofuran; H₂O

3: hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂

4: CF₃CO₂H

5: (EtO)2P(O)CN, Et₃N / CH₂Cl₂

6: CF₃CO₂H

7: (EtO)2P(O)CN, Et₃N / CH₂Cl₂

8: HOBT / methanol

With sodium hydroxide; diethyl cyanophosphonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00149a001