N^α-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide

Base Information

• Chemical Name: N^α-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide
• CAS No.: 138971-59-2
• Molecular Formula: C₄₅H₆₁N₁₁O₁₂
• Molecular Weight: 948.046

Synonyms:

Chemical Property of N^α-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide

Chemical Property:

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Technology Process of N^α-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide

There total 5 articles about N^α-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C46H61N9O13 → Nα-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide (138971-59-2)

Guidance literature:

With hydrazine hydrate; In N,N-dimethyl-formamide; for 15h; Yield given;

Reference yield:

(S)-4-tert-Butoxycarbonylamino-4-[(S)-2-(1H-imidazol-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-butyric acid tert-butyl ester → Nα-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide (138971-59-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄*H₂O / methanol / 15 h

2: isopentyl nitrite, 1.98 N HCl / dimethylformamide; tetrahydrofuran / 0.67 h / -30 °C

3: Et₃N / dimethylformamide; tetrahydrofuran / 1.17 h / -15 °C

4: N₂H₄*H₂O / dimethylformamide / 15 h

With hydrogenchloride; hydrazine hydrate; triethylamine; isopentyl nitrite; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

Nα-tert-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidine Hydrazide (138971-58-1) → Nα-t-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycine Hydrazide (138971-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1: isopentyl nitrite, 1.98 N HCl / dimethylformamide; tetrahydrofuran / 0.67 h / -30 °C

2: Et₃N / dimethylformamide; tetrahydrofuran / 1.17 h / -15 °C

3: N₂H₄*H₂O / dimethylformamide / 15 h

With hydrogenchloride; hydrazine hydrate; triethylamine; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

N^α-tert-Butoxycarbonyl-L-(γ-tert-butoxy)glutamyl-L-histidine Hydrazide

L-Histidine methyl ester

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