4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid

Base Information

Chemical Name:4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid
CAS No.:943741-05-7
Molecular Formula:C₁₇H₁₇BN₂O₄
Molecular Weight:324.144
Hs Code.:

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Chemical Property of 4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid

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Technology Process of 4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid

There total 4 articles about 4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 943741-05-7
4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid

Guidance literature:

Reference yield:

: 866930-93-0
2-(4-bromo-2-methylphenyl)ethanol

: 943741-05-7
4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

1.2: 2 h / -78 - 20 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; 2.1: |Miyaura Borylation Reaction;
DOI:10.1021/acs.jmedchem.6b00244

Reference yield:

: 116632-39-4
2-methyl-4-bromoiodobenzene

: 943741-05-7
4-(2-(3-cyanophenylcarbamoyloxy)ethyl)-3-methylphenylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium fluoride; tetrabutyl-ammonium chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 0.5 h / 170 °C / Inert atmosphere; Molecular sieve; Microwave irradiation

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0.25 h / 120 °C / Sealed tube; Microwave irradiation

2.2: 0 - 30 °C / Sealed tube

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

3.2: 2 h / -78 - 20 °C

4.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

With potassium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl-ammonium chloride; potassium acetate; sodium hydride; 9-bora-bicyclo[3.3.1]nonane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dimethyl sulfoxide; toluene; mineral oil; 4.1: |Miyaura Borylation Reaction;
DOI:10.1021/acs.jmedchem.6b00244