(3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

Base Information

Chemical Name:(3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester
CAS No.:864683-05-6
Molecular Formula:C₂₅H₃₈NO₁₀P
Molecular Weight:543.551
Hs Code.:

(3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Property of (3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

Chemical Property:

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Technology Process of (3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

There total 2 articles about (3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 864683-03-4
(3'S,4R)-5-(4-benzhydryl-2-oxo-oxazolidin-3-yl)-4-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-5-oxo-pentanoic acid tert-butyl ester

: 864683-05-6
(3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O₂; LiOH / tetrahydrofuran; H₂O / 0.5 h / 0 °C

2: 0.15 g / methanol / 0.25 h / 20 °C

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo0507439

Reference yield:

: (3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 864683-05-6
(3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: In methanol; at 20 ℃; for 0.25h;
DOI:10.1021/jo0507439

Reference yield:

: 864683-05-6
(3'S,2R)-2-[(3'-benzyloxycarbonylamino-3'-methoxy-carbonyl-propyl)-methoxy-phosphinoylmethyl]-pentane-1,5-dioic acid 5-tert-butyl ester 1-methyl ester

: (3'S,2R)-2-[[[3'-carboxy-3'-[[4''-[[(2''',4'''-diamino-6'''-pteridinyl)methyl]methylamino]benzoyl]amino]propyl]-hydroxyphosphinoyl]methyl]-pentane-1,5-dioic acid tris(triethylamine) salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / HCl / 12 h / Heating

2.1: tetramethylguanidine / dimethylsulfoxide / 18 h / 20 °C

2.2: 79 percent / DEAE-cellulose

With hydrogenchloride; 1,1,3,3-tetramethylguanidine; In dimethyl sulfoxide;
DOI:10.1021/jo0507439