-7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

Base Information

Chemical Name:-7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride
CAS No.:146929-49-9
Molecular Formula:C₂₇H₃₄N₄O₄*ClH
Molecular Weight:515.052
Hs Code.:

<R-(R*,R*)>-7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

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Chemical Property of -7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

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Technology Process of -7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

There total 8 articles about -7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96551-27-8
α-methyl-(R)-tryptophan methyl ester

: 146929-49-9
-7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: 99 percent / LiOH / dioxane; H₂O / 24 h / Ambient temperature

3: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et₃N / 1) ethyl acetate, rt, 2 h, 2) overnight

4: 98 percent / H₂ / 20percent Pd/C / methanol / 4 h

5: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight

6: LiOH / dioxane; H₂O / 3 h / Ambient temperature

7: 3 M HCl / ethyl acetate / 3 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)86257-8

Reference yield:

: 146953-09-5
α-methyl-N-<(phenylmethoxy)carbonyl>-D-tryptophan

: 146929-49-9
-7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et₃N / 1) ethyl acetate, rt, 2 h, 2) overnight

2: 98 percent / H₂ / 20percent Pd/C / methanol / 4 h

3: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight

4: LiOH / dioxane; H₂O / 3 h / Ambient temperature

5: 3 M HCl / ethyl acetate / 3 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)86257-8

Reference yield:

: 141971-07-5
methyl α-methyl-N-<(phenylmethoxy)carbonyl>-D-tryptophanate

: 146929-49-9
-7-<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-7-oxoheptanoic acid monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / LiOH / dioxane; H₂O / 24 h / Ambient temperature

2: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide, 2) Et₃N / 1) ethyl acetate, rt, 2 h, 2) overnight

3: 98 percent / H₂ / 20percent Pd/C / methanol / 4 h

4: 1) 1-hydroxy-1H-benzotriazole, dicyclohexyl carbodiimide / 1) ethyl acetate, 2 h, rt, 2) overnight

5: LiOH / dioxane; H₂O / 3 h / Ambient temperature

6: 3 M HCl / ethyl acetate / 3 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; water; ethyl acetate;
DOI:10.1016/S0040-4020(01)86257-8