1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine

Base Information

Chemical Name:1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine
CAS No.:1027546-51-5
Molecular Formula:C₁₅H₂₀ClF₃N₂O₂S
Molecular Weight:384.85
Hs Code.:
DSSTox Substance ID:DTXSID901141305

Synonyms:DTXSID901141305;1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine;1027546-51-5

Suppliers and Price of 1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:384.0886112
Heavy Atom Count:24
Complexity:488

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CC2=CC(=CC=C2)C(F)(F)F)S(=O)(=O)CCCCl

Technology Process of 1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine

There total 1 articles about 1-[(3-Chloropropyl)sulfonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1633-82-5
3-chloro-n-propanesulfonyl chloride

: 55513-16-1
N-[3-(trifluoromethyl)benzyl]piperazine

: 1027546-51-5
1-(3-Chloro-propane-1-sulfonyl)-4-(3-trifluoromethyl-benzyl)-piperazine

Guidance literature:: In ethyl acetate; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.43.1511

Reference yield:

: 1027546-51-5
1-(3-Chloro-propane-1-sulfonyl)-4-(3-trifluoromethyl-benzyl)-piperazine

: 3-[4-(3-Trifluoromethyl-benzyl)-piperazine-1-sulfonyl]-propane-1-thiol

Guidance literature:: With potassium hydrosulfide; In methanol; ethanol; at 70 ℃; for 1h;
DOI:10.1248/cpb.43.1511

Reference yield:

: 1027546-51-5
1-(3-Chloro-propane-1-sulfonyl)-4-(3-trifluoromethyl-benzyl)-piperazine

: 6-{3-[4-(3-Trifluoromethyl-benzyl)-piperazine-1-sulfonyl]-propylsulfanyl}-imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: KSH / methanol; ethanol / 1 h / 70 °C

2: NaOMe / methanol / 1.5 h / 100 °C

With sodium methylate; potassium hydrosulfide; In methanol; ethanol;
DOI:10.1248/cpb.43.1511