N-2,N⁶-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine

Base Information

• Chemical Name: N-2,N⁶-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine
• CAS No.: 145118-32-7
• Molecular Formula: C₄₁H₅₂N₆O₇
• Molecular Weight: 740.9

Synonyms:

Chemical Property of N-2,N⁶-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N-2,N⁶-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine

There total 6 articles about N-2,N⁶-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.4%

2-(2-indolyl)acetic acid 4-nitrophenyl ester (5157-45-9) + N-(L-Alanyl)-N'-2,N6-bis<(benzyloxy)carbonyl>-L-lysyl>hexane-1,6-diamine Hydrochloride (145118-31-6) → N-2,N6-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine (145118-32-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; methanol; for 18h;

DOI:10.1002/hlca.19920750617

Reference yield:

4-nitrophenyl N2,N6-bis[(phenylmethoxy)carbonyl]-L-lysinate (21160-82-7) → N-2,N6-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine (145118-32-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 94.9 percent / Et₃N / tetrahydrofuran / 40 h

2: 94.3 percent / HCl / dioxane / 0.67 h

3: 71.1 percent / Et₃N / tetrahydrofuran / 18 h

4: 95.8 percent / HCl / dioxane / 0.67 h

5: 49.4 percent / Et₃N / tetrahydrofuran; methanol / 18 h

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1002/hlca.19920750617

Reference yield:

N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride (65915-94-8) → N-2,N6-Bis<(Benzyloxy)carbonyl>-L-lysyl>-N'--L-alanyl>hexane-1,6-diamine (145118-32-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 94.9 percent / Et₃N / tetrahydrofuran / 40 h

2: 94.3 percent / HCl / dioxane / 0.67 h

3: 71.1 percent / Et₃N / tetrahydrofuran / 18 h

4: 95.8 percent / HCl / dioxane / 0.67 h

5: 49.4 percent / Et₃N / tetrahydrofuran; methanol / 18 h

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol;

DOI:10.1002/hlca.19920750617

upstream raw materials:

2-(2-indolyl)acetic acid 4-nitrophenyl ester

N-(L-Alanyl)-N'-2,N⁶-bis<(benzyloxy)carbonyl>-L-lysyl>hexane-1,6-diamine Hydrochloride

4-nitrophenyl N₂,N₆-bis[(phenylmethoxy)carbonyl]-L-lysinate

N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride

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