4-(4-hydroxyphenyl)furan-2(5H)-one

Base Information

• Chemical Name: 4-(4-hydroxyphenyl)furan-2(5H)-one
• CAS No.: 7706-90-3
• Molecular Formula: C10H8 O3
• Molecular Weight: 176.172
• Mol file: 7706-90-3.mol

Synonyms:2(5H)-Furanone,4-(p-hydroxyphenyl)- (8CI); Cinnamic acid, p-hydroxy-b-(hydroxymethyl)-, g-lactone (7CI); NSC 224286

Chemical Property of 4-(4-hydroxyphenyl)furan-2(5H)-one

Chemical Property:

• Vapor Pressure: 1.58E-07mmHg at 25°C
• Boiling Point: 416.5°Cat760mmHg
• Flash Point: 194.8°C
• Density: 1.353g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-hydroxyphenyl)furan-2(5H)-one

There total 10 articles about 4-(4-hydroxyphenyl)furan-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(4-methoxyphenyl)furan-2(5H)-one (3516-65-2) → 4-(4-hydroxyphenyl)furan-2(5H)-one (7706-90-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.tetlet.2017.06.016

Reference yield: 95.0%

(p-hydroxyphenyl)boronic acid (71597-85-8) + trifluoromethanesulfonic acid 5-oxo-2,5-dihydrofuran-3-yl ester (157123-01-8) → 4-(4-hydroxyphenyl)furan-2(5H)-one (7706-90-3)

Guidance literature:

(p-hydroxyphenyl)boronic acid; trifluoromethanesulfonic acid 5-oxo-2,5-dihydrofuran-3-yl ester; With sodium carbonate; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 70 ℃; for 16h; Reagent/catalyst; Solvent; Time; Catalytic behavior; Inert atmosphere;

DOI:10.1002/ejoc.201700158

Reference yield: 85.0%

→ 4-(4-hydroxyphenyl)furan-2(5H)-one (7706-90-3)

Guidance literature:

With potassium carbonate; In acetone; at 20 - 40 ℃; for 1h;

With 18-crown-6 ether; In acetonitrile; at 55 ℃; for 5h;

upstream raw materials:

2,4’-diacetoxyacetophenone

ethyl bromoacetate

benzene

4-(4-methoxyphenyl)furan-2(5H)-one

Downstream raw materials:

(Z)-4-(4-hydroxyphenyl)-5-(4-methoxybenzylidene)furan-2(5H)-one

(Z)-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one

(Z)-5-((2,2-dimethylchroman-6-yl)methylene)-4-(4-hydroxyphenyl)furan-2(5H)-one

4-(4-hydroxyphenyl)-5-[(Z)-(4-hydroxyphenyl)methylidene]furan-2-one