4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester

Base Information

• Chemical Name: 4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester
• CAS No.: 183861-30-5
• Molecular Formula: C₂₀H₂₄F₃N₃O₅
• Molecular Weight: 443.423
• Mol file: 183861-30-5.mol

Synonyms:

Chemical Property of 4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester

There total 1 articles about 4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one (72331-40-9) → 4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester (183861-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2 h / Ambient temperature

2: 45 percent / TMS-triflate / CH₂Cl₂ / 24 h / Ambient temperature

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; acetonitrile;

DOI:10.1080/07328319608002457

Reference yield:

4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester (183861-30-5) → N-[4,5-dihydroxy-4,5-O-di-p-nitrobenzoyl-1-(2-oxo-2,3,4,7-tetrahydro[1,3]diazepin-1-yl)-pentyl]-2,2,2-trifluoroacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / K₂CO₃ / ethanol / 1 h / Ambient temperature

2: 36 percent / pyridine / 2 h / Ambient temperature

With potassium carbonate; In pyridine; ethanol;

DOI:10.1080/07328319608002457

Reference yield:

4-Methyl-benzoic acid 2-hydroxy-5-(2-oxo-2,3,4,7-tetrahydro-[1,3]diazepin-1-yl)-5-(2,2,2-trifluoro-acetylamino)-pentyl ester (183861-30-5) → N-[4,5-dihydroxy-4,5-O-di-p-nitrobenzoyl-1-(3-p-nitrobenzoyl-2-oxo-2,3,4,7-tetrahydro[1,3]diazepin-1-yl)-pentyl]-2,2,2-trifluoroacetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / K₂CO₃ / ethanol / 1 h / Ambient temperature

2: 10 percent / pyridine / 2 h / Ambient temperature

With potassium carbonate; In pyridine; ethanol;

DOI:10.1080/07328319608002457

upstream raw materials:

1,3,4,7-tetrahydro-2H-1,3-diazepin-2-one