2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester
• CAS No.: 224575-48-8
• Molecular Formula: C₄₃H₅₇N₃O₈SSi
• Molecular Weight: 804.092
• Mol file: 224575-48-8.mol

Synonyms:

Chemical Property of 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester

There total 2 articles about 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazol-2-ylsulfanylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester → 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester (224575-48-8)

Guidance literature:

With ammonium molibdate; dihydrogen peroxide; In ethanol; water;

DOI:10.1016/S0040-4039(99)00210-5

Reference yield:

2,2-Dimethyl-propionic acid 2-{(2R,6R)-6-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-(2-hydroxymethyl-oxazol-4-yl)-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester (224578-37-4) → 2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester (224575-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: DIAB, PPh₃ / tetrahydrofuran

2: (NH₄)2MoO₄, H₂O₂ / H₂O; ethanol

With ammonium molibdate; [bis(acetoxy)iodo]benzene; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; ethanol; water;

DOI:10.1016/S0040-4039(99)00210-5

Reference yield:

2,2-Dimethyl-propionic acid 2-((2R,6R)-6-{(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-[2-(1-methyl-1H-imidazole-2-sulfonylmethyl)-oxazol-4-yl]-tetrahydro-pyran-2-ylmethyl}-4-methylene-tetrahydro-pyran-2-yl)-ethyl ester (224575-48-8) → C52H64N2O8Si

Guidance literature:

Multi-step reaction with 10 steps

1: n-BuLi / diethyl ether / -78 °C

2: CH₂Cl₂

3: SmI₂ / tetrahydrofuran

4: PPTs / ethanol / 48 h / Heating

5: LiOH / tetrahydrofuran; methanol; H₂O

6: 96 percent / imidazole / dimethylformamide

7: 80 percent / DMAP / toluene / Heating

8: 77 percent / PPTs / ethanol

9: 70 percent / Dess-Martin periodinane, NaHCO₃ / CH₂Cl₂

10: K₂CO₃, 18-crown-6 / toluene

With 1H-imidazole; dmap; lithium hydroxide; n-butyllithium; samarium diiodide; 18-crown-6 ether; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(99)00210-5

upstream raw materials:

2,2-Dimethyl-propionic acid 2-{(2R,6R)-6-[(2R,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-(2-hydroxymethyl-oxazol-4-yl)-tetrahydro-pyran-2-ylmethyl]-4-methylene-tetrahydro-pyran-2-yl}-ethyl ester