Technology Process of (3S,5R)-5-Hydroxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester
There total 5 articles about (3S,5R)-5-Hydroxy-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C16H28N2O9S;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
With
lithium hydroxide;
In
1,4-dioxane; water;
at 0 - 2 ℃;
for 0.833333h;
DOI:10.1246/cl.2001.1172
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 80 percent / imidazole / CHCl3 / 6.5 h / 0 - 20 °C
2.1: LDA / tetrahydrofuran / 0.33 h / -78 °C
2.2: CH2Cl2 / 0.67 h / -78 °C
3.1: 80 percent / TBAF / tetrahydrofuran / 1 h / 20 °C
4.1: 84 percent / Et3N / CHCl3 / 1 h / 0 - 20 °C
5.1: NaH / dimethylformamide / 1 h / 0 - 20 °C
5.2: 68 percent / 1M LiOH / dioxane; H2O / 0.83 h / 0 - 2 °C
With
1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1246/cl.2001.1172
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LDA / tetrahydrofuran / 0.33 h / -78 °C
1.2: CH2Cl2 / 0.67 h / -78 °C
2.1: 80 percent / TBAF / tetrahydrofuran / 1 h / 20 °C
3.1: 84 percent / Et3N / CHCl3 / 1 h / 0 - 20 °C
4.1: NaH / dimethylformamide / 1 h / 0 - 20 °C
4.2: 68 percent / 1M LiOH / dioxane; H2O / 0.83 h / 0 - 2 °C
With
tetrabutyl ammonium fluoride; sodium hydride; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1246/cl.2001.1172
