Technology Process of germacrene B
There total 15 articles about germacrene B which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
chromium chloride; samarium; samarium diiodide;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Red-Al / toluene / 0.25 h / -78 °C
2: 1.) N,N,N',N'-tetramethylethylenediamine, BuLi, 2.) TMPDCl, 3.) Li, EtNH2 / 1) THF, hexane, 78 deg C, 15 min; 2) THF, hexane, -78 deg C, 5 min, rt, 1 h; 3) THF, hexane, 0 deg C, 25 min
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; TMPDCl; lithium; ethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
toluene;
DOI:10.1021/jo970901z
- Guidance literature:
-
Multi-step reaction with 10 steps
1: Ph3P; CCl4 / 1 h / Heating
2: m-chloroperbenzoic acid / CH2Cl2 / 1 h / 0 °C
3: 72 percent / HIO4*2H2O / tetrahydrofuran; diethyl ether / 1 h / 0 °C
4: KCN*18-crown-6 / 12 h / 4 °C
5: PhCH2NMe3F / H2O; tetrahydrofuran / 2 h / 20 °C
6: p-TsOH / benzene / 3 h / 0 °C
7: 48 percent / NaN(SiMe3)2 / tetrahydrofuran / 0.5 h / 70 °C
8: pyridinium p-toluenesulfonate / methanol / 6 h / 40 °C
9: NaOH / H2O; diethyl ether / 0.05 h
10: 82 percent / Sm; SmI2; CrCl3 / tetrahydrofuran / 0.5 h / 20 °C
With
tetrachloromethane; chromium chloride; sodium hydroxide; samarium; samarium diiodide; (K-18-crown-6 ether) cyanide; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; trimethyl(benzyl)ammonium fluoride; toluene-4-sulfonic acid; periodic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; benzene;
1: Chlorination / 2: Epoxidation / 3: Oxidation / 4: Addition / 5: Hydrolysis / 6: Etherification / 7: Cyclization / 8: Deetherification / 9: Hydrolysis / 10: Alkylation;
