2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine

Base Information

Chemical Name:2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine
CAS No.:950685-80-0
Molecular Formula:C₁₄H₂₀N₂O₆S
Molecular Weight:344.389
Hs Code.:

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Chemical Property of 2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine

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Technology Process of 2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine

There total 6 articles about 2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 950685-79-7
2,5'-O-cyclo-3'-O-acetyl-4'-C-methoxymethylene thymidine

: 950685-80-0
2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine

Guidance literature:: With hydrogen sulfide; In pyridine; at 45 ℃; for 288h; under 17251.7 Torr;
DOI:10.1002/chem.200601627

Reference yield:

: 851345-90-9
3'-O-tert-butyldimethylsilyl-5'-O-tert-butyldiphenylsilyl-4'-C-methoxymethylenethymidine

: 950685-80-0
2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / BF₃*OEt₂ / CH₂Cl₂ / 4 h / 20 °C

2: 4-(N,N-dimethylamino)pyridine / pyridine / 20 °C

3: 904 mg / tetrabutylammonium fluoride / tetrahydrofuran / 3.5 h

4: 2,6-lutidine / CH₂Cl₂ / -50 - 20 °C

5: 213 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 14 h / -20 °C

6: 28 percent / H₂S / pyridine / 288 h / 45 °C / 17251.7 Torr

With 2,6-dimethylpyridine; dmap; boron trifluoride diethyl etherate; hydrogen sulfide; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; pyridine; dichloromethane; acetonitrile;
DOI:10.1002/chem.200601627

Reference yield:

: C₁₅F₃H₁₉SN₂O₉

: 950685-80-0
2-thio-3'-O-acetyl-4'-C-methoxymethylene thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 213 mg / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 14 h / -20 °C

2: 28 percent / H₂S / pyridine / 288 h / 45 °C / 17251.7 Torr

With hydrogen sulfide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; acetonitrile;
DOI:10.1002/chem.200601627