(1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester

Base Information

• Chemical Name: (1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester
• CAS No.: 151520-56-8
• Molecular Formula: C₃₀H₅₂O₅Si
• Molecular Weight: 520.825
• Mol file: 151520-56-8.mol

Synonyms:

Chemical Property of (1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester

There total 1 articles about (1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-triisopropylsilyloxyetienic acid methyl ester → (1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester (151520-56-8)

Guidance literature:

With ozone; acetic acid; zinc; Multistep reaction;

DOI:10.1021/jm00078a022

Reference yield:

(1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester (151520-56-8) → (1S,3aS,4S,5S,7aS)-4-Carboxymethyl-7a-methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-octahydro-indene-1-carboxylic acid methyl ester (151520-57-9)

Guidance literature:

With chromium(VI) oxide; sulfuric acid;

DOI:10.1021/jm00078a022

Reference yield:

(1S,3aS,4S,5S,7aS)-7a-Methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-4-(2-oxo-ethyl)-octahydro-indene-1-carboxylic acid methyl ester (151520-56-8) → (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid benzylamide

Guidance literature:

Multi-step reaction with 11 steps

1: CrO₃, H₂SO₄

2: oxalyl chloride, pyridine

3: NaN₃

4: SiO₂ (silica gel)

6: TBAF

7: PDC

8: LiOH aq.

9: SOCl₂, pyridine

11: TFA

With pyridine; chromium(VI) oxide; lithium hydroxide; dipyridinium dichromate; thionyl chloride; sodium azide; oxalyl dichloride; sulfuric acid; tetrabutyl ammonium fluoride; silica gel; trifluoroacetic acid;

DOI:10.1021/jm00078a022

Downstream raw materials:

(1S,3aS,4S,5S,7aS)-4-Carboxymethyl-7a-methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-octahydro-indene-1-carboxylic acid methyl ester

6-azasteroid

(1S,3aS,4S,5S,7aS)-4-Chlorocarbonylmethyl-7a-methyl-5-((1R,4S)-1-methyl-2-oxo-4-triisopropylsilanyloxy-cyclohexyl)-octahydro-indene-1-carboxylic acid methyl ester

(1S,3aS,3bS,9aR,9bS,11aS)-1-Benzylcarbamoyl-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridine-5-carboxylic acid tert-butyl ester