(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester
CAS No.:166169-34-2
Molecular Formula:C₄₈H₆₂N₄O₅S₂
Molecular Weight:839.176
Hs Code.:

(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

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Chemical Property of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

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Technology Process of (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

There total 7 articles about (S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 166169-34-2
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

2: 4 N HCl, dimethyl sulfide / CH₂Cl₂; dioxane / 1 h

3: 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

With hydrogenchloride; dimethylsulfide; 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm950642a

Reference yield:

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 166169-34-2
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NMP, diisopropylethylamine, hydroxybenzotriazole, diisopropylethylamine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 4 deg C, 5 min, 2.) CH₂Cl₂, RT, 16 h

2: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

3: 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

4: 4 N HCl, dimethyl sulfide / CH₂Cl₂; dioxane / 1 h

5: 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; dimethylsulfide; 3 A molecular sieve; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm950642a

Reference yield:

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 166169-34-2
(S)-2-({(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-butyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NMP, diisopropylethylamine, hydroxybenzotriazole, diisopropylethylamine, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 4 deg C, 5 min, 2.) CH₂Cl₂, RT, 16 h

2: 99 percent / 4 N HCl / CH₂Cl₂; various solvent(s); dioxane / 1 h

3: 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

4: 4 N HCl, dimethyl sulfide / CH₂Cl₂; dioxane / 1 h

5: 3 Angstroem molecular sieves, glacial acetic acid, NaBH₃CN / methanol / 16 h / Ambient temperature

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; dimethylsulfide; 3 A molecular sieve; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm950642a