2,3-Diiodopyrazine

Base Information

• Chemical Name: 2,3-Diiodopyrazine
• CAS No.: 58139-07-4
• Molecular Formula: C₄H₂I₂N₂
• Molecular Weight: 331.882
• European Community (EC) Number: 870-467-0
• DSSTox Substance ID: DTXSID101315972
• Nikkaji Number: J980.770E
• Mol file: 58139-07-4.mol

Synonyms:2,3-diiodopyrazine;58139-07-4;di-iodopyrazine;SCHEMBL10699475;DTXSID101315972;DB-181606;N13386;EN300-7436429

Chemical Property of 2,3-Diiodopyrazine

Chemical Property:

• Boiling Point: 321.6±42.0 °C(Predicted)
• PKA: -3.70±0.10(Predicted)
• Density: 2.765±0.06 g/cm3(Predicted)
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 331.83074
• Heavy Atom Count: 8
• Complexity: 68.4

Purity/Quality:

98% ^*data from raw suppliers

2,3-Diiodopyrazine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN=C(C(=N1)I)I

Technology Process of 2,3-Diiodopyrazine

There total 2 articles about 2,3-Diiodopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3-dichloropyrazine (4858-85-9) → 2,3-diiodopyrazine (58139-07-4)

Guidance literature:

With sulfuric acid; acetic acid; sodium iodide; In acetonitrile; for 24h; Reflux;

DOI:10.1021/jo300034h

Reference yield:

2-iodopyrazine (32111-21-0) → 2,3-diiodopyrazine (58139-07-4)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; iodine; Yield given. Multistep reaction; 1.) THF, -78 deg C, 5 min, 2.) THF, -78 deg C, 60 min;

DOI:10.1016/S0040-4020(98)00526-2

Reference yield: 75.0%

3-((4,5-bis(dodecyloxy)-2-ethynylphenyl)ethynyl)pyridine (1361114-12-6) + 2,3-diiodopyrazine (58139-07-4) → 2,3-bis((4,5-bis(dodecyloxy)-2-(pyridin-3-ylethynyl)phenyl)-ethynyl)pyrazine (1361113-90-7)

Guidance literature:

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; triethylamine; XPhos; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo300034h

upstream raw materials:

2-iodopyrazine

2,3-dichloropyrazine

Downstream raw materials:

2,3-bis((4,5-bis(dodecyloxy)-2-(pyridin-2-ylethynyl)phenyl)-ethynyl)pyrazine

2,3-bis((4,5-bis(dodecyloxy)-2-(pyridin-3-ylethynyl)phenyl)-ethynyl)pyrazine

2,3-bis((4,5-bis(dodecyloxy)-2-(pyridin-4-ylethynyl)phenyl)-ethynyl)pyrazine