Phosphonic acid, [[[[2-(acetyloxy)-1-[[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]oxy]meth yl]ethoxy]methyl]ethoxyphosphinyl]methyl]-, diethyl ester

Base Information

Chemical Name:Phosphonic acid, [[[[2-(acetyloxy)-1-[[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]oxy]meth yl]ethoxy]methyl]ethoxyphosphinyl]methyl]-, diethyl ester
CAS No.:139177-45-0
Molecular Formula:C₂₄H₃₅N₃O₁₁P₂
Molecular Weight:603.503
Hs Code.:

Phosphonic acid,
[[[[2-(acetyloxy)-1-[[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]oxy]meth
yl]ethoxy]methyl]ethoxyphosphinyl]methyl]-, diethyl ester

Synonyms:

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Chemical Property of Phosphonic acid, [[[[2-(acetyloxy)-1-[[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]oxy]meth yl]ethoxy]methyl]ethoxyphosphinyl]methyl]-, diethyl ester

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Technology Process of Phosphonic acid, [[[[2-(acetyloxy)-1-[[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]oxy]meth yl]ethoxy]methyl]ethoxyphosphinyl]methyl]-, diethyl ester

There total 6 articles about Phosphonic acid, [[[[2-(acetyloxy)-1-[[[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]oxy]meth yl]ethoxy]methyl]ethoxyphosphinyl]methyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 139177-39-2
4-benzamido-1-hydroxyuracil

: 139177-38-1
(R,S)-diethyl <(1-acetoxymethyl-2-hydroxy)ethoxymethyl(ethoxy)phosphoryl>methylphosphonate

: 139177-45-0
(R,S)-1-<2-acetoxymethyl-2-<(diethoxyphosphorylmethyl)(ethoxy)phosphorylmethoxy>ethoxy>-4-benzamidouracil

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

Reference yield:

: 74992-34-0
O,O-diethyl diethoxyphosphinomethylphosphonate

: 139177-45-0
(R,S)-1-<2-acetoxymethyl-2-<(diethoxyphosphorylmethyl)(ethoxy)phosphorylmethoxy>ethoxy>-4-benzamidouracil

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / a) 120 deg C, 18 h, b) 180 deg C, 15 min.

2: 85 percent / HCl / 10percent Pd-charcoal / aq. ethanol / 3 h / 760 Torr / Ambient temperature

3: 1) toluene-4-sulphonic acid, 2) 10percent AcOH / 1) r.t., 1 h, 2) r.t., 30 min.

4: 71 percent / Ph₃P, diethyl azodicarboxylate / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 139211-45-3
4-benzamido-1-benzyloxyuracil

: 139177-45-0
(R,S)-1-<2-acetoxymethyl-2-<(diethoxyphosphorylmethyl)(ethoxy)phosphorylmethoxy>ethoxy>-4-benzamidouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / H₂, HCl / 10percent Pd-charcoal / tetrahydrofuran; H₂O; methanol / 0.22 h / 760 Torr / Ambient temperature

2: 71 percent / Ph₃P, diethyl azodicarboxylate / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;