p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Base Information

Chemical Name:p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate
CAS No.:133076-30-9
Molecular Formula:C₇₇H₆₄N₈O₁₀S₄
Molecular Weight:1389.67
Hs Code.:

p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

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Chemical Property of p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

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Technology Process of p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

There total 10 articles about p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116240-90-5
p-methoxybenzyl 7-amino-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

: 133076-23-0
(Z)-2-(2-tritylaminothiazol-4-yl)-2-<3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino>acetic acid

: 133076-30-9,133076-37-6,138514-60-0
p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: With trichlorophosphate; In dichloromethane; at -20 - -10 ℃; for 2h;
DOI:10.1248/cpb.38.3476

Reference yield:

: 76-83-5
trityl chloride

: 133076-30-9,133076-37-6,138514-60-0
p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

2: 1N NaOH / methanol

3: 580 mg / ethanol; CHCl₃ / 17 h / Ambient temperature

4: 520 mg / POCl₃ / CH₂Cl₂ / 2 h / -20 - -10 °C

With sodium hydroxide; trichlorophosphate; In methanol; ethanol; dichloromethane; chloroform;
DOI:10.1248/cpb.38.3476

Reference yield:

: 131580-89-7
3-Diphenylmethoxy-4-pyrone

: 133076-30-9,133076-37-6,138514-60-0
p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 530 mg / NaOH / H₂O; methanol / 10 h / 80 °C

2: 1) 5percent HCl / 1) water, 5 deg C, 2) CH₂Cl₂, 1 h

3: 624 mg / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1 h / 5 °C

4: hydrazine monohydrate / CH₂Cl₂ / 1 h / 5 °C

5: 580 mg / ethanol; CHCl₃ / 17 h / Ambient temperature

6: 520 mg / POCl₃ / CH₂Cl₂ / 2 h / -20 - -10 °C

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water;
DOI:10.1248/cpb.38.3476