(S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide

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Chemical Name:(S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide
CAS No.:1159488-58-0
Molecular Formula:C₃₁H₂₈F₆N₄O₂
Molecular Weight:602.579
Hs Code.:

(S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide

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Chemical Property of (S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide

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Technology Process of (S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide

There total 2 articles about (S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260227-27-7
{4-[(1R)-2,2-difluoro-1-hydroxyethyl]phenyl}boronic acid

: 1159489-45-8
C₂₃H₂₁BrF₄N₄O

: 1159488-58-0
(S)-N-[(S)-cyano-(4-cyano-2-fluoro-benzyl)-methyl]-2-{(S)-1-[4'-((R)-2,2-difluoro-1-hydroxy-ethyl)-biphenyl-4-yl]-2,2,2-trifluoro-ethylamino}-3-methyl-butyramide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/j.bmcl.2010.10.015