(R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Base Information

Chemical Name:(R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.:1189569-53-6
Molecular Formula:C₃₄H₃₂F₂N₄O₂
Molecular Weight:566.65
Hs Code.:

(R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Chemical Property of (R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Technology Process of (R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

There total 6 articles about (R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189569-86-5
(R)-5-bromo-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

: 1448055-90-0
(8R)-8-(3,5-difluorophenyl)-6,8-dimethyl-9-(prop-2-yn-1-yl)-6,9-diazaspiro[4.5]decan-10-one

: 1189569-53-6
(R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ml400199p

Reference yield:

: 957122-14-4
tert-butyl 2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propanoate

: 1189569-53-6
(R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2.1: acetic acid / methanol / 0.5 h / 20 °C

2.2: 0.5 h / pH 5

3.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

4.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

5.1: acetic acid; sodium cyanoborohydride / methanol / 43 h / 20 - 50 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

6.2: 23 h / Cooling with ice

7.1: copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400199p

Reference yield:

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 1189569-53-6
(R)-5-(3-((R)-8-(3,5-difluorophenyl)-6,8-dimethyl-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)prop-1-yn-1-yl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 0.5 h / pH 5

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

3.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

4.1: acetic acid; sodium cyanoborohydride / methanol / 43 h / 20 - 50 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 23 h / Cooling with ice

6.1: copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium cyanoborohydride; acetic acid; triethylamine; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400199p