(R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

Base Information

Chemical Name:(R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide
CAS No.:274928-69-7
Molecular Formula:C₂₅H₄₁N₉O₅S
Molecular Weight:579.724
Hs Code.:

(R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

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Technology Process of (R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

There total 12 articles about (R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 334953-05-8
C₄₁H₅₂N₁₀O₁₁S

: 274928-69-7
(R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; water; acetic acid;
DOI:10.1016/S0960-894X(00)00105-0

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 274928-69-7
(R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 81 percent / ZnCl₂ / diethyl ether; tetrahydrofuran / -30 - 0 °C

2: aq. HCl / ethanol

3: HCl

4: 23 percent / Et₃N; DMAP / dioxane

5: H₂; PtO₂ / ethanol; acetic acid; H₂O

6: tetrahydrofuran

7: 100 percent / HCl / ethanol

8: NMM / acetonitrile

9: 1N LiOH / ethanol

10: EDC; HOBt; NMM / acetonitrile

11: H₂ / 10 percent Pd/C / ethanol; acetic acid; H₂O

With 4-methyl-morpholine; hydrogenchloride; dmap; platinum(IV) oxide; lithium hydroxide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; zinc(II) chloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; acetic acid; acetonitrile; 1: Ugi reaction / 2: Hydrolysis / 3: Esterification / 4: Acylation / 5: Catalytic hydrogenation / 6: guanylation / 7: deprotection / 8: Acylation / 9: Hydrolysis / 10: coupling / 11: Hydrogenolysis;
DOI:10.1016/S0960-894X(00)00105-0

Reference yield:

: 180250-77-5
Ng-nitroargininal ethyl cyclol hydrochloride

: 274928-69-7
(R)-N-[((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-ylcarbamoyl)-methyl]-2-(1-carbamimidoyl-piperidin-4-yl)-2-phenylmethanesulfonylamino-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; HOBt; NMM / acetonitrile

2: H₂ / 10 percent Pd/C / ethanol; acetic acid; H₂O

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; water; acetic acid; acetonitrile; 1: coupling / 2: Hydrogenolysis;
DOI:10.1016/S0960-894X(00)00105-0