2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester

Base Information

• Chemical Name: 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester
• CAS No.: 443688-52-6
• Molecular Formula: C₁₄H₁₉BrO₅
• Molecular Weight: 347.206
• Mol file: 443688-52-6.mol

Synonyms:

Chemical Property of 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester

There total 4 articles about 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethoxybutanoic acid (10374-37-5) → 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester (443688-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂; HBr / diethyl ether

2: oxalyl chloride; pyridine / CH₂Cl₂

3: Et₃N / CH₂Cl₂

With pyridine; oxalyl dichloride; hydrogen bromide; bromine; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(03)00346-9

Reference yield:

diethyl 2-ethoxyethylmalonate (13487-89-3) → 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester (443688-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. KOH / ethanol / Heating

2: Br₂; HBr / diethyl ether

3: oxalyl chloride; pyridine / CH₂Cl₂

4: Et₃N / CH₂Cl₂

With pyridine; potassium hydroxide; oxalyl dichloride; hydrogen bromide; bromine; triethylamine; In diethyl ether; ethanol; dichloromethane;

DOI:10.1016/S0960-894X(03)00346-9

Reference yield:

2-bromo-4-ethoxy-butyric acid (443688-47-9) → 2-bromo-4-ethoxy-butyric acid 2,6-dimethoxy-phenyl ester (443688-52-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; pyridine / CH₂Cl₂

2: Et₃N / CH₂Cl₂

With pyridine; oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1016/S0960-894X(03)00346-9

upstream raw materials:

1,3-dimethoxy-2-hydroxy-benzene

2-bromo-4-ethoxy-butyryl chloride

4-ethoxybutanoic acid

diethyl 2-ethoxyethylmalonate

Refernces