<1S-(1R,2S,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

Base Information

Chemical Name:<1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide
CAS No.:135704-01-7
Molecular Formula:C₃₃H₅₃N₇O₆S₂
Molecular Weight:707.959
Hs Code.:

<1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

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Chemical Property of <1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

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Technology Process of <1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

There total 3 articles about <1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 135704-09-5
4-((S)-1-{(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-[2-(2,2,2-trichloro-ethoxycarbonylamino)-thiazol-4-yl]-ethylcarbamoyl}-2-phenyl-ethylsulfamoyl)-piperazine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

: 135704-01-7,135819-25-9
<1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; methanol; for 9.5h; Ambient temperature;
DOI:10.1021/jm00092a006

Reference yield:

: 135704-27-7
4-((S)-1-Carboxy-2-phenyl-ethylsulfamoyl)-piperazine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

: 135704-01-7,135819-25-9
<1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

2: 72 percent / Zn, NH₄Cl / tetrahydrofuran; methanol / 9.5 h / Ambient temperature

With ammonium chloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006

Reference yield:

: 135704-33-5
{4-[(S)-2-Amino-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-thiazol-2-yl}-carbamic acid 2,2,2-trichloro-ethyl ester

: 135704-01-7,135819-25-9
<1S-(1R*,2S*,3R*)>-N-(1-piperazinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-L-alaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

2: 72 percent / Zn, NH₄Cl / tetrahydrofuran; methanol / 9.5 h / Ambient temperature

With ammonium chloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006